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These agents reduce the amount of proinflammatory cytokines, such as interleukin (IL) 17A and tumor necrosis factor- (TNF-) that play a role in keratinocyte hyperproliferation and the inflammation that characterizes psoriatic plaques
More remarkably, 14.1% of participants on the 9 mg dose and 12.0% on the 12 mg dose were completely free of knee pain by the end of the trial
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It also covered laboratory tests (organized using Logical Observation Identifiers Names and Codes) and healthcare utilization records from a network of 79 healthcare organizations including hospitals, primary care facilities, and specialist care providers
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