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J Virology 1984;52:739-744

The synergistic effect often allows for lower individual doses while maintaining efficacy, potentially reducing some side effects associated with higher single-peptide concentrations

[4] Stibolt T

Despite this issue, we need to know: How are opioids interacting with chronic pain in the brain? Without this data, no one knows what long term opioid use does to the brain in chronic pain patients

These side effects, including changes in diastolic blood pressure, are typically dose-dependent, meaning they may be more pronounced with higher doses