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Body composition changes require 4-8 weeks of consistent use to become noticeable

For comprehensive food guides, see best foods to eat on semaglutide , what to eat on tirzepatide , and foods to avoid on semaglutide

The combination also affects blood sugar regulation and may increase risk of low blood sugar episodes, particularly if you're taking other diabetes medications alongside your GLP-1 therapy

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Real-world data from a Truveta study of over 18,000 patients found that tirzepatide users achieved greater weight loss at 12 months compared to semaglutide users, consistent with the SURMOUNT-5 findings [4]