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Disease-specific oligodendrocyte lineage cells arise in multiple sclerosis

The extract also modulates cytokine balance by decreasing levels of IL-1, IL-6, TNF-, IFN-, and increasing IL-10, alongside downregulating mRNA and protein expression of inflammatory mediators like IL-6, TGF-, and MMP-2.Mechanistically, the extract exerts anti-RA effects by inhibiting TLR4-mediated NF-B nuclear translocation, thereby suppressing inflammatory signaling cascades, and activating the SIRT1-Nrf2/HO-1 signaling axis to enhance antioxidant capacity