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While human clinical trials remain limited, decades of animal research and growing community experience suggest a favorable risk profile when used responsibly
It needs to be tolerant
Curr Pharm Des 16:12241234 Sikiric P, Seiwerth S, Rucman R, et al
Ketamine and psilocybin each produce a brief acute experience but set off a wave of synaptic growth afterward, ketamine through glutamate release and mTOR-dependent synapse formation and psilocybin through rapid, lasting growth of dendritic spines in the frontal cortex, both via BDNF signaling, which is why a single session can shift symptoms for weeks
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