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Splitting, chewing, or crushing the tablet also breaks down this barrier, making the drug less effective

Effect of neoadjuvant chemotherapy plus regional hyperthermia on long-term outcomes among patients with localized high-risk soft tissue sarcoma: the EORTC 62961-ESHO 95 randomized clinical trial

They bind to the same receptors but resist the enzymatic breakdown (by DPP-4) that rapidly degrades natural GLP-1

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KYNA is generally thought to have neuroprotective, antioxidant, and anticonvulsant effects, although inhibiting 7nAChRs has been linked to emotional and cognitive disturbances