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During this process, PLA particles were colonized by gut microbes, forming surface biofilms and increasing pullulanase activityan enzyme that degrades branched polysaccharidesthe authors suggested this may have broken down PLA into smaller carbon-rich molecules, potentially supporting Bifidobacterium growth, without triggering pathogenic overgrowth or inflammatory responses (Jimnez-Arroyo et al., 2023)

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To tackle challenges, new approaches are underway: combining antifungal drugs, developing fungal vaccines, creating innovative medications (including small - molecule peptides and nanoparticles), extracting actives from traditional Chinese medicine, and leveraging AI for drug designall aiming to improve fungal infection management (D)

ER, Endoplasmic reticulum

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