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Patients in the treatment arm survived a median 13.3 months without disease progression, while those in the control group lived only 4.4 months without their disease advancing

It is a short acidic peptide because both glutamic acid and aspartic acid contain additional carboxyl groups

4,5,6,7-tetrabromo-2-azabenzamidazole (TBB), which specifically inhibits casein kinase 2 (CK2), was selected and discovered to preferentially trigger apoptosis in Zmpste24 / cells

Why study this combination

Furthermore, because of the possibility of adverse effects on a nursing infant, this therapy is generally avoided in women who are breastfeeding