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The drug administration methods were intraperitoneal (i.p.) injection 60 min before the formalin injection

Hypoxic regions activate HIF-1, driving a shift toward glycolytic metabolism, whereas oxygen-rich zones sustain robust mitochondrial respiration and energy production [106]

TMPRSS6, also known as matriptase-2, negatively regulates the production of hepcidin and is a membrane-bound serine protease expressed in hepatocytes