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Thus, by its enzymatic detoxification of nonradical hydroperoxides, GPx-1 regulates cellular oxidant status directly through elimination of hydroperoxides and via oxidation of GSH, the major low-molecular-weight thiol in cells

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It is present in virtually every cell of the body, where it acts as a primary shield against free radicals

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Long-term glutathione supplementation has been associated with reduced zinc concentrations, which can result in many health problems