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Gastrointestinal distension by ISF significantly reduced short-term food intake without aversive behavior, and this effect was significantly attenuated by pretreatment with GLP-1R antagonist or chemical ablation of vagal sensory neurons (Fig

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It also means allergic reactions are unlikely, though not impossible, since any foreign substance can theoretically trigger sensitivity in susceptible individuals

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An animal study concluded that fenugreek seeds significantly decreased triglycerides and cholesterol concentration