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Contraindication Signals Standard conservative practice excludes anyone with active gastrointestinal disease, type 1 diabetes, prior pancreatitis, medullary thyroid carcinoma history, or active cancer from any tirzepatide protocol

9,10 Summary A large body of high-quality evidence suggests that in patients with obesity without diabetes, GLP-1 and GIP/GLP-1 receptor agonists are associated with significant regain of lost weight after therapy discontinuation

In a pilot study, 12 diabetic subjects being treated with metformin were examined as they discontinued and then re-started their metformin treatment