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Muscle preservation matters significantly (older adults, athletes, people with sarcopenia risk)

Comprehensive studies have shown an increase in quality of life12 and an average decrease in swelling of 50%

If symptoms suggest a new endocrine problem, baseline testing is reasonable before starting therapy, with a follow-up check at three months for the standard panels: HbA1c, fasting glucose, TSH, and free T4 if on thyroid therapy, morning cortisol only when clinically indicated, and sex hormones if symptoms arise

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Patients taking warfarin alongside semaglutide should have INR monitoring when initiating treatment