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PLoS ONE 11 , e0146797 (2016)

Specific Clinical Relevance Osteoarthritis GLP-1's primary advantage in OA is its dual capacity to modulate synovial macrophage polarization (M1M2) while directly inhibiting cartilage matrix-degrading enzymes (MMP-3, MMP-13, ADAMTS-4/5) and promoting COL2 and aggrecan synthesis

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Statistical test Data were subjected to analysis of variance (ANOVA) and Tukey's honestly significant difference (HSD) multiple comparisons were conducted using ProStat software Version 5.5(Poly Software International Inc., Pearl River, NY)

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