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Important safety warnings include: Acute pancreatitis : Seek urgent medical care if you experience sudden, severe and persistent abdominal pain (which may radiate to your back), with or without vomiting Diabetic retinopathy complications : Patients with pre-existing retinopathy should be monitored closely, especially during rapid improvement in blood glucose control Dehydration risk : The gastrointestinal side effects may cause dehydration, potentially leading to acute kidney injury

Over time, this leads to nerve damage, or diabetic neuropathy

Cost Impacts to Health Plans Rising Pharmacy Costs: Health plans could face a 20%35% increase in overall pharmacy spending for members with diabetes or obesity

Clinical Effectiveness Clinical studies have shown that semaglutide significantly reduces body weight and improves glycemic control when used consistently, along with diet and exercise