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The FDA reviewed both animal and human data in allulose's GRAS notices , including a study by Iida et al

When stored properly at -20C in a sealed container away from direct light and moisture, lyophilized BPC-157 remains stable for 24-36 months from the date of manufacture

This oxidative damage is particularly severe in the substantia nigra in PD, where dopamine-producing neurons are especially vulnerable to ROS (Liu et al., 2025)