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The evidence from both protective and at-risk IFIH1 variants highlights the critical role of the type I IFN pathway in T1D pathogenesis

5 Referral of the patient to a nephrologist is important, as complications such as volume overload, anaemia, electrolyte imbalances and CKD-related mineral and bone disorders can become prominent management issues when the eGFR declines to below the cut-off

Oxidative stress and osteoporosis

The Pharmaceutical Response: DPP-4 Inhibitors The pharmaceutical industry recognized this limitation and developed DPP-4 inhibitor drugsmedications like sitagliptin (Januvia), saxagliptin (Onglyza), and linagliptin (Tradjenta)

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