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Unfortunately, with about 3,100 known causative mutations in over 50 different genes, each gene target would require a unique treatment [4]

The tryptophan residue at the N-terminus gives it a characteristic UV absorbance profile used for laboratory identification

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and proteins Aldolase superfamily protein (F4IC59), Leucine aminopeptidase 2 (Q944P7), Thiol protease aleurain-like (Q8RWQ9), Reactive Intermediate Deaminase A (Q94JQ4), Proteasome subunit alpha type-2-B (Q8L4A7) showed no significant differences, but had lower expression in T4 than T3