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Natural human GLP-1 exists primarily as GLP-1(7-36) amide, a peptide that is rapidly degraded by DPP-4, resulting in a half-life of only 2 to 3 minutes

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The American Diabetes Associations Standards of Care in Diabetes2025 have recommended the use of GLP-1RAs in patients with T2DM, symptomatic heart failure with preserved ejection fraction, and obesity [40]