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Based on these observations, Gregorio Weber pointed out in 1975: From these results it can be definitely concluded that the time-average structure observed by X-ray diffraction is something of an abstraction, since it is not itself widelyor even sparselyrepresented at any given time in the population of molecules Indeed the protein molecule model resulting from the X-ray crystallographic observations is a platonic protein, well removed in its perfection from the kicking and screaming stochastic molecule that we infer must exist in solution

and Schallreuter K.U

Lilly Sees Biotech Funding Decline As Acquisition Opportunity Eli Lilly views the current downturn in biotech funding as an opportune moment for strategic acquisitions

Pedruzzi LM, Stockler-Pinto MB, Leite MJ, Mafra D

Eur J Biochem 267:49124916 Franco R, Schoneveld OJ, Pappa A, Panayiotidis MI (2007) The central role of glutathione in the pathophysiology of human diseases