Factors affecting potassium levels Potassium physiology Approximately 98% of total body potassium is stored intracellularly, while 2% is in serum.[9] In normal kidney function, the kidney is responsible for approximately 90% of potassium excretion, while colonic excretion accounts for approximately 10%.[10] This intra- and extracellular difference in potassium levels is maintained by several complex mechanisms, including sodiumpotassium pumps and hormonal regulation
17 Compounding the issue is the fact that various professional organizations and grading references (the American Academy of Pediatrics, American Family Practice, Scottish Intercollegiate Guidelines Network, and many others) have different letter assignments and cutoffs for the use of non-RCT-containing literature, creating confusion about the meaning of an A, B, or C to denote the quality of literature used for evidence
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Toxicol Appl Pharmacol 2017;335:56-63