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Because both are CNS stimulants with overlapping mechanisms, co-administration significantly elevates the risk of cardiovascular events, including dangerously elevated heart rate, high blood pressure, and arrhythmia

Human cytomegalovirus also affects astrocytes and reduces astrocytic production of thrombospondins, 261 such affecting synaptogenesis, and suppresses astrocytic expression of glutamate transporters, 262 thus decreasing neuroprotection again excitotoxic damage

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52 Interestingly, low zinc levels have been associated with pediatric inflammatory bowel disease 55 and increased inflammation in animal models of colitis 56 and zinc supplementation appears to be protective of bowel inflammation in clinical 57 and animal studies