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In addition, A1R signaling inhibits excitatory synaptic transmission through the inhibition of glutamate release, ionotropic glutamate receptors, and neuronal excitability via inward rectifying, cAMP/PKA/DARPP-32 pathway, as well as calcium-activated potassium channels (61, 62)

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Selenate is converted to adenosine 5-phosphoselenate (APSe) via ATP sulfurylase (Figure 2, step 1), then changed to selenite through adenosine phosphosulfate reductase (Figure 2, step 2)

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1) as a surrogate measure of LOX activity in solubilized samples 21