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Our previous studies (30) documented that ROS are involved in the formation of WRS-induced gastric mucosal damage due to an enhancement of lipid peroxidation and attenuation of mucosal antioxidative mechanisms

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Except for linagliptin, which is eliminated via a biliary route, all other DPP-4 inhibitors are excreted in the urine ( DPP-4 inhibitors are contraindicated in type 1 diabetes as well as during pregnancy and lactation

Adequate fluid intake should be maintained