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Protein interacting with C kinase 1 (PICK1), which binds to the GluR2 via the PDZ domain [37], provides binding domains for PKC and glutamate receptor-interacting proteins (GRIP), which ultimately helps in phosphorylation and the internalization of AMPAR [37,38,39]

Plot a scenario where you stop for six weeks and then resume at your full maintenance dose

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While these preliminary findings suggest potential benefit, larger randomized, placebo-controlled trials are necessary, and at present there is insufficient evidence to make strong recommendations regarding the clinical use of acamprosate or other GABAergic agents in ASD (181)