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Endoplasmic reticulum stress and oxidative stress: a vicious cycle or a double-edged sword

During the early stages of acute pancreatitis, the inflammatory response damages the intestinal barrier, allowing bacteria and endotoxins to enter the blood, triggering an inflammatory storm, sepsis, and even multiple organ failure [92]

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Theoretical (mechanistic): the HGF/c-Met pathway governs growth, proliferation, and angiogenesis and is dysregulated in some cancers, so chronic potentiation raises a theoretical oncological concern