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1 Endometriotic lesions undergo tissue breakdown in response to progesterone withdrawal at the end of the menstrual cycle

Reference: Forman HJ (2016)

The initial approved regimen was 5 g subcutaneous injection twice daily, given within 60 minutes before morning and evening meals, titratable to 10 g BID

Guedes RL, Prosdocimi F, Fernandes GR, Moura LK, Ribeiro HA, Ortega JM