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Clinically validated biomarkers of OS, such as F2-isoprostanes (which indicate lipid peroxidation), 8-OHdG (which indicates DNA damage), and the activities of redox enzymes like superoxide dismutase (SOD) and glutathione peroxidase (GPx), show strong correlations with disease progression and end-organ complications

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also reported that BSO treatment increased colon tumorigenesis, but it did not shorten mouse survival 21

A few users reported headaches and small skin bumps, which disappeared after discontinuing use

The inherent anti-inflammatory and antioxidant effects of melatonin also contribute to the overall health of the male reproductive system