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The reason its LogD does not decrease appreciably after it is deprotonated is, again, because the negative charge is delocalized within the molecule in internal hydrogen bonding, such that it becomes a lipophilic anion and so can act as the all-important intramembrane proton shunt (28)

Effects of dietary astaxanthin and xanthophylls on the growth and skin pigmentation of large yellow croaker Larimichthys croceus

The first escalation doubles the dose, which sounds aggressive but represents the smallest absolute increase in the protocol

Influence of chloroquine or acid treatment of human platelets on the antigenicity of HLA and the thrombocyte-specific glycoproteins Ia/IIa, IIb, and IIb/IIIa

Serum erythropoietin concentration in chronic renal failure: relationship to degree of anemia and excretory renal function