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Herskowitz: Its an old story

Why Storage Rules Exist: The Chemistry Behind Stability Peptide degradation in solution occurs through three primary chemical pathways: hydrolysis (water cleaves the peptide backbone, most rapid at elevated temperature and acidic or alkaline pH), oxidation (methionine, cysteine, and tryptophan side chains react with dissolved oxygen or photocatalytic radicals), and deamidation (asparagine and glutamine residues lose an amide group, producing aspartate or glutamate and altering the peptide's charge and receptor binding)

doi: 10.1016/j.arcmed.2014.11.015 19 BrochardV.CombadireB.PrigentA.LaouarY.PerrinA.Beray-BerthatV.et al

Care 18 , 225 (2014)

Bracket Position 2 Place the TAN patch directly on the pain point and place the WHITE patch on the opposite side of the body