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Oral dosing studies have used comparable per-kilogram doses with demonstrable efficacy

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These anti-inflammatory actions are further potentiated by TCM-derived phytochemicals, which synergistically suppress NLRP3/ASC/caspase-1 complex formation, reduce IL-1 maturation, and modulate TGF-/Smad pathway phosphorylation, ultimately attenuating renal fibrotic responses (111, 112)

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Extracellular SOD has also been shown to decrease in human OA cartilage, suggesting that extracellular SOD also plays a key role in regulating ROS in cartilage (Regan et al., 2005)