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The most commonly reported adverse effects in Phase 2 trials were gastrointestinal in nature, including: Nausea (the most frequently reported) Vomiting Diarrhoea Constipation Decreased appetite These effects were generally dose-dependent and most pronounced during dose escalation, typically improving over time

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if severe, it may require phototherapy (ultraviolet light to photoisomerize bilirubin into a nontoxic form) or exchange blood transfusion to prevent damage to the brain (kernicterus)