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Both cells were cultured at 37C with 5% CO 2 , generally subcultured every 23 days, and regularly tested for mycoplasma using mycoblue mycoplasma Detector (D101-02, Vazyme)

High-altitude exposure induces increased phosphorylation of Dynamin-related protein-1 (Drp1), a key regulator of mitochondrial division, resulting in excessive mitochondrial fission and subsequent fragmentation

Think of it as flipping a switch on fat cells that tells them to release their contents

Are you, you know, playing in the dirt

By pumping the accumulated, unbound cytosolic catecholamines backward across the plasma membrane and safely into the extracellular synaptic space, the neuron is able to maintain its free cytoplasmic neurotransmitter levels below toxic thresholds , directly protecting itself from oxidative cell death and preserving neuronal viability (Underhill et al., 2021)