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Brutsaert DL, Fransen P, Andries LJ, Keulenaer GWD, Sys SU (1998) Cardiac endothelium and myocardial function

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Timing alone doesnt confirm a diagnosis, but it is a useful clinical clue when assessing patterns over time

The thiol-disulfide equilibrium within the cell is known to regulate a diverse number of metabolic processes including enzyme activity, transport activity, signal transduction, and gene expression via alteration of redox sensitive transcription factors such as activator protein-1 (AP-1), nuclear factor kappa B (NFB) and p53 (Hutter et al., 1997