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Acknowledgements This work was supported by grants SAF2015-65267-R (MINECO, Spain), S2017/BMD-3684 MOIR2-CM (Comunidad de Madrid, Spain), CIBERdem (ISCIII, Spain), INFLAMES (ISCIII PIE14/00045, co-funded by ERDF, Investing in your future), European Foundation for the Study of Diabetes (EFSD) and H2020 Marie Sklodowska-Curie ITN-TREATMENT (Grant Agreement Number 721236) (European Commission) to A.M.V

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