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Oral versus intramuscular administration of vitamin B12 for vitamin B12 deficiency in primary care: A pragmatic, randomized, multicenter, non-inferiority clinical trial

At 14 weeks of age, mice were randomized into treatment groups ( n = 8 per group) receiving subcutaneous injections of PG-102 (15, 30, 60, or 120 nmol/kg), semaglutide (30 nmol/kg), tirzepatide (15 nmol/kg), or vehicle every 3 days for 12 weeks

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Importantly, these phenotypes frequently coexist, so that many high-risk patients qualify for both classes, necessitating integrated and often combination-based treatment strategies (Fig

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