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Calcium-dependent kinases may be involved in the gene expression cascade for browning

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The opportunities in these indications can be assessed by deploying effective new product planning / opportunity assessment methodologies, including evaluating the following for each potential indication: Level of in-class / competitive activity Likelihood of technical and regulatory success (i.e., based on scientific rationale and regulatory precedent) Level and nature of unmet needs for new therapies in the disease area of interest Potential for GLP1-s to address these unmet needs Commercial attractiveness of market Potential speed to market Alignment with individual manufacturer portfolio / strategy / capabilities Conclusion Incretin mimetics have had an immense and growing impact on patient outcomes

Debatri Datta March 11, 2024 Written By Dr

GLP-1 acts on pancreatic to stimulate insulin secretion and improve islet cell function, on cells to increase glucose sensitivity and inhibit glucagon secretion, and on cells to stimulate growth inhibitory hormone release (Holst, 2007), whereas in the stomach, GLP-1 not only inhibits the secretion of gastrointestinal glands but also inhibits gastric motility (especially gastric emptying) and gastric acid secretion (Zhang et al., 2022)