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Lyn tyrosine kinase is required for P2X 4 receptor upregulation and neuropathic pain after peripheral nerve injury

No pharmacokinetic studies to assess the effects of race have been performed, but in placebo-controlled studies of glimepiride tablets in patients with Type 2 diabetes, the antihyperglycemic effect was comparable in whites (n = 536), blacks (n = 63), and Hispanics (n = 63)

In contrast to the results of our previous experiments performed using pancreatic islets (i.e., those in which GEP44-mediated effects were more prominent in the presence of the Y1-R antagonist), we found that GEP44 directly increased glucose uptake in muscle tissue to a similar degree to that elicited by PYY 1-36 and that GEP44-mediated glucose uptake was inhibited by Y1-R antagonism

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