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In some instances, the addition of a secondary polymer (e.g., a thickening agent) and a pH of formulation as described herein, allows for sterilization of a formulation described herein without any substantial degradation of the otic agent and/or the polymer components in the otic formulation

The appropriate concentration varies significantly by assay type and cell line

RA patients on the other hand, display high levels of autoantibodies in their sera that target joint components including collagen and cartilage, stress proteins, and nuclear proteins (Steiner 2007)

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The use of antidepressants targeting this aspect of neurotransmission has shown to normalize the activity of HPA axis, decreasing the levels of CRH and consequently also ACTH and cortisol (252)