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Panieri E, Telkoparan-Akillilar P, Saso L
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4 Adverse events in PIONEER 3 1,4 Comparator AE rates are not an adequate basis for comparison of safety between products 1 Because clinical trials are conducted under widely varying conditions, AE rates observed in the clinical trials of a drug cannot be directly compared with rates in the clinical trials of another drug and may not reflect the rates observed in practice 1 AE=adverse event
The NICE ethnic BMI adjustment NICE guideline NG246 (2025) sets a lower obesity threshold of BMI 27.5 for people from South Asian, Chinese, Other Asian, Middle Eastern, Black African, and African-Caribbean backgrounds 3
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