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While TNFR1 signaling results in the undesirable pro-inflammatory effects of TNF-, TNFR2 signaling is known to induce favorable responses that include immune cell homeostasis and tissue remodeling 52,53,54

In a second cohort that was given polyclonal IgG from vaccinated macaques or control animals, loss of TGF- and increased IL-6 production by activated pulmonary macrophages was observed in macaques that were pre-treated with anti-S IgG, and lung pathology was described as skewed towards immunopathological inflammation

Inflammatory responses enhance the production of ROS, which further amplify inflammation in turn