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GLP-1R is expressed in the AP and nucleus of the solitary tract (NTS) located in the hindbrain, and c-Fos expression after GLP-1RA injection was apparent in hindbrain GLP-1R cells, with further studies demonstrating these cells role in mediating GLP-1RA actions [59,96,102,103]

155 Furthermore, GDH-derived NADPH is consumed to support the reductive carboxylation of -KG by IDH2, and the compensatory increase in the expression of GDH1 or GDH2 promote the growth of IDH-mutant glioma cells

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The effects of n-acetylcysteine and/or deferoxamine on manic-like behavior and brain oxidative damage in mice submitted to the paradoxal sleep deprivation model of mania