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Patients were randomized to receive either weekly subcutaneous semaglutide 2.4 mg or placebo, with the dose gradually increased over 16 weeks to minimize gastrointestinal side effects

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Swab the top of the rubber stopper with an alcohol wipe and allow it to air dry completely

Gradual weight loss is safer Patients with severe pain from acute cholecystitis, persistent symptoms despite medication or complications generally require cholecystectomy

Acknowledgements We would like to acknowledge the hard and dedicated work of all the staff that implemented the intervention and evaluation components of the study