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The neuroprotective cannabinoids effects in MS have been ascribed to the stimulation of CB1R, the most abundant GPCR in the brain, whereas CB2R has been associated with immunomodulatory effects (Mecha et al., 2020)

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Furthermore, this patient subgroup reported increased adverse events related to weight loss (ROR = 10.85, 95% CI 9.1212.91) and metabolic disturbances

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