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No randomized trials No controlled studies No validated imaging or outcome measures Only one very small, biased case series 2
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Mechanistically, targeting CD38 improved T cell glucose metabolism and mitochondrial mass in vitro, attenuated hippocampal glucose hypometabolism, as well as cortical IL-1-driven inflammation in vivo, an AD hallmark associated with disease progression 71,72 , linking metabolism and immunity 73
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