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Clinical Chemistry and Laboratory Medicine , 49 (11), 17731782
Skin repair mechanisms and related signaling pathways are mediated by different genes, such as AQP3 (encoding a protein responsible for transporting water and glycerol, participating in the skin lipid metabolism, and regulating the differentiation and proliferation of keratinocytes in the wound-healing process), COL2A (encoding the main fibrous protein of skin ECM), FGF2 (encoding an angiogenic and mitogenic factor stimulating the cells proliferation and migration at the wound site), ITGB (encoding the main ECM adhesion transmembrane molecule), SEPTIN4 (encoding a GTP-binding protein involved in the morphogenesis and physiological functions of many cells, like skin cells), as well as FGF7, FGFR2, PPARD, and STAT3 8,9,10,11,12,13,14,15,16
y.o., years old
This result suggested that So-2, a natural compound isolated from traditional Chinese medicine, might be a potential ferroptosis-related therapeutic agent for combating TNBC ( Table 1 )
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