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The results also showed that participants were less willing to associate with the individual who regained weight after stopping medication compared to the person who maintained weight loss

doi: 10.1056/NEJMoa2108269 86 HernandezAFGreenJBJanmohamedSDAgostinoRBGrangerCBJonesNPet al

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The GLP-1RA liraglutide significantly reduces the eosinophilia and the production of type-2 cytokines species like IL-5 and IL-13 in the respiratory tract, while GLP-1R signaling downregulates innate allergic inflammation [135]

Based on these findings, inhibiting GSK3 could be a novel therapeutic strategy for the treatment of patients with T2DM, not only by enhancing insulin sensitivity, but also by improving insulin secretion