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Collectively, these observations suggested that binding of EC and CH causes a substantial reduction in protein essential motions against C3G and ARB inhibitor during the initial interval of MD simulation which eventually equilibrated to a stable conformation as a function of 100 ns interval

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This mixture was vortexed to mix properly and centrifuged at 13000 g for 30 min

The sequences of specific primers used for RT-qPCR in this study are listed in Supplementary Table S1

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