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It works by blocking the NNMT enzyme in fat cells and other tissues, which prevents the conversion of nicotinamide to 1-methylnicotinamide

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Mean liver fat reduction was 82.4% by MRI-PDFF, with 86% of participants who had MASLD (metabolic-associated steatotic liver disease) at baseline achieving complete resolution (liver fat below 5%)

It is likely that much of the beneficial effect of Lipoic Acid may be attributed to its ability to increase levels of Glutathione, chelate metals (such as iron and copper), quench diverse free radicals, and recycle antioxidants