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Reviews Endocr Metabolic Disorders

So this speaks to a very important issue which we have to look at obesity is probably a majority of persons as being a chronic health condition for which theyre going to need long-term ongoing care and you would need to take these medications indefinitely just like I take my hypertensive or cholesterol medication indefinitely

[3] White, J

Hammerle SP, Mindeholm L, Launonen A, et al

Researchers who have studied it understand the core mechanism: GLP-1 receptor (GLP-1R) agonism produces glucose-dependent insulin secretion from pancreatic beta cells, suppresses glucagon release from alpha cells, slows gastric emptying, and engages hypothalamic appetite circuits specifically the arcuate nucleus to reduce caloric intake through neuropeptide Y/AgRP suppression and POMC/CART activation